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Post by jim on Jul 4, 2013 22:24:23 GMT -5
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Post by sandy07 on Jul 5, 2013 0:22:40 GMT -5
Retinoic acid....is this not used in a skin treatment..wrinkles, dark spots or something? It sounds familiar.
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Post by jim on Jul 5, 2013 2:16:52 GMT -5
Yes you are right Sandy, it is used in skin treatments.
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Deleted
Deleted Member
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Post by Deleted on Jul 5, 2013 12:42:13 GMT -5
Wish they would put a rush on those trials..
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Post by John on Jul 5, 2013 12:44:35 GMT -5
Thanks Jim
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Post by paul on Aug 6, 2014 11:49:36 GMT -5
anyone know where they are doing clinical trials for this retinoic acid to treat emphysema?
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Post by al on Aug 7, 2014 1:33:54 GMT -5
They have been experimenting with this for some years;
It's a form of Vitamin A
I think they are now using (9-cis RA )
Lots of info on google !
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Post by jim on Aug 7, 2014 6:11:01 GMT -5
Thanks for your input Al and for pointing us in the right direction, I'll be looking up on Google as soon as find some spare time.
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Post by stoker55 on Aug 8, 2014 14:34:49 GMT -5
It doesn't work on my face hope it works in the lungs.  |
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Post by Vic on Aug 8, 2014 15:09:25 GMT -5
As I recall, about 6 to 8-years ago in California (I believe it was UCLA), they ran a lengthy trial called the FORTE (Feasibility Of Retinoic Acid in Emphysema) trial. It worked well on mice, but the results were not good for humans. -- Vic
EDIT: Make that: (Feasibility Of Retinoic acid to Treat Emphysema)
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Post by al on Aug 8, 2014 21:35:19 GMT -5
Retinoid induction of alveolar regeneration: from mice to man? M Hind1,2, Å Gilthorpe2, S Stinchcombe2, M Maden2 + Author Affiliations 1 Department of Respiratory Medicine, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London, UK 2 MRC Centre for Developmental Neurobiology, King’s College London, London, UK Dr M Hind, Department of Respiratory Medicine, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London SW3 6NP, UK; m.hind@imperial.ac.uk Received 1 August 2008 Revised  October 2008 Abstract The use of retinoids to induce human lung regeneration is under investigation in a number of studies in patients with chronic obstructive pulmonary disease (COPD). Retinoic acid (RA) has complex pleiotropic functions during vertebrate patterning and development and can induce regeneration in a number of different organ systems. Studies of retinoid signalling during lung development might provide a molecular basis to explain pharmacological induction of alveolar regeneration in adult models of lung disease. In this review the role of endogenous RA signalling during alveologenesis is explored and data suggesting that a number of exogenous retinoids can induce regeneration in the adult lung are discussed. Current controversies in this area are highlighted and a hypothesis of lung regeneration is put forward. Understanding the cellular and molecular mechanisms of induction of regeneration will be central for effective translation into patients with lung disease and may reveal novel insights into the pathogenesis of alveolar disease and senescence. READ MORE----- thorax.bmj.com/content/64/5/451.full |
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Post by David on Aug 8, 2014 22:50:42 GMT -5
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October 2008 