Anti-inflammatory nanomolecules enable tissue regeneration

[al]

Anti-inflammatory nanomolecules enable tissue regeneration




Anti-inflammatory nanomolecules enable tissue regeneration

Anyone who has suffered an injury can probably remember the after-effects, including pain,
swelling or redness. These are signs that the body is fighting back against the injury. When tissue
in the body is damaged, biological programs are activated to aid in tissue regeneration. An
inflammatory response acts as a protective mechanism to enable repair and regeneration, helping
the body to heal after injuries such as wounds and burns. However, the same mechanism may
interfere with healing in situations in which foreign material is introduced, for example when
synthetics are grafted to skin for dermal repair. In such cases, the inflammation may lead to
tissue fibrosis, which creates an obstacle to proper physiological function.
The research group of Arun Sharma, PhD has been working on innovative approaches to tissue
regeneration in order to improve the lives of patients with urinary bladder dysfunction. Among
their breakthroughs was a medical model for regenerating bladders using stem cells harvested
from a donor's own bone marrow, reported in the Proceedings of the National Academy of
Sciences in 2013.
More recently, the team has developed a system that may protect against the inflammatory
reaction that can negatively impact tissue growth, development and function. Self-assembling
peptide amphiphiles (PAs) are biocompatible and biodegradable nanomaterials that have
demonstrated utility in a wide range of settings and applications. Using an established urinary
bladder augmentation model, the Sharma Group treated a highly pro-inflammatory biologic
scaffold used in a wide array of settings with anti-inflammatory peptide amphiphiles (AIF-PAs).
When compared with control PAs, the treated scaffold showed regenerative capacity while
modulating the innate inflammatory response, resulting in superior bladder function.
This work is published in the journal Biomaterials. Says Sharma, "Our findings are very relevant
not just for bladder regeneration but for other types of tissue regeneration where foreign
materials are utilized for structural support. I also envision the potential utility of these
nanomolecules for the treatment of a wide range of dysfunctional inflammatory based
conditions."
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[David]

Thanks for posting this, Al. I try and keep up with all the latest findings. That was interesting.

www.feinberg.northwestern.edu/news/2014/08/Sharma-biomaterials.html

[jim]

Thank you Al and David, it is always nice to read/learn new things.

[John]

Thanks Al and David .