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Post by gerald on Jul 16, 2017 19:45:41 GMT -5
It is good to see they are pursuing continued testing. We can hope for some positive results from theit study -------------------------------------- Losartan Effects on Emphysema Progression (LEEP) Sponsor: Johns Hopkins University Collaborator: University of Pittsburgh A randomized, parallel, placebo controlled trial to evaluate the effect of 100mg/day losartan on the progression of emphysema as measured by quantitative HRCT compared to placebo Detailed Description: This is a pragmatic trial designed to test if a treatment, losartan, may decrease the progression of Chronic Obstructive Pulmonary Disease (COPD). Losartan is an angiotensin receptor blocking agent, commonly used as an antihypertensive agent, which has been shown to alter cardiac remodeling after myocardial infarction and renovascular remodeling in diabetes-mellitus. In this trial participants with mild to severe COPD, with Computed Tomography (CT) evidence of emphysema (5-35% of voxels with < -950 Hounsfield Units), will be randomly assigned to receive 100mg/day of losartan or placebo for 48 weeks. The primary outcome measure will be the rate of progression of emphysema, quantified as the percent of lung voxels with a density less than -950 HU as measured by High Resolution CT (HRCT, from baseline to 48 weeks. clinicaltrials.gov/ct2/show/NCT02696564?recrs=a&cond=copd&cntry1=NA%3AUS&state1=NA%3AUS%3AIL&rank=9 |
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Post by bluebird on Jul 16, 2017 21:39:37 GMT -5
Interesting aeticle! Is losartan a heart med?
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Post by gerald on Jul 17, 2017 14:22:08 GMT -5
Losartyn is high blood pressure medication. I buy it under its brand name Cozaar.
It has been around since the 60's. Very few side effects.
John Hopkins started studying Losartyn for COPD about 4 years ago. Their second round of studies showed that it only worked for Emphysema not Bronchitus etc.
Might be something to talk with a doctor about.
The only cautionery note is to start it slowly and build up the dosage.
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