Hello everyone

[Blossom/Jackie W.]

Jeff, I was going to ask what it is but looked it up(a couple others had also mentioned it)and read the posts here as well... duh.... I should have done that first

For anyone reading.....you could also check
en.wikipedia.org/wiki/Copper_peptide_GHK-Cu

I wish I could help you out there but I can't. What I will tell you though is that I wouldn't be adding it, or anything, to my nebulizer w/o checkiong with a Dr or the pharmacist.

I read that David was going to check with his Dr about alternatives to the IV administering but That was in May and he hasn't mentioned it since.

BTW..... just to forewarn you...... we may move this thread over to the COPD portal later so that more folks will see it but if we do, we'll leave a note and a link to it.

[susanny]

\Hi Jeff. I have been nebulizing for several years now but have never heard of 'ghk'. Do you know what the letters stand for and could you possibly put up the link to the site that you found it on?

Sorry, the 2nd page didn't come up until I'd posted my reply. I'll have to go look at the link that Blossom put up. But first off I would definitely agree with her to check with your dr before adding anything to your nebulizer. It's the same as taking any drug and needs to be ok'd.



d

[susanny]

OK Jeff, I read the link and below are the points that seem to relate to emphysema.

Genomic studies

Recent genomic research suggests that GHK directly modulates gene expression, which may explain the diversity of its biological actions. Iorio et al. used a repository of transcriptional responses to compounds, the Connectivity Map (cMap),[28] and MANTRA software to explore networks of compounds producing similar transcriptional responses. GHK, as one of the compounds studied, increased mRNA production in 268 genes while suppressing 167.[29] GHK was found to reverse the gene-expression signature of emphysematous destruction found in lung tissue obtained from smokers with COPD (Chronic Obstructive Pulmonary Disease). The gene expression signature associated with emphysema severity included 127 genes, involved in inflammation and repair. Using the Connectivity Map, researchers established that the peptide GHK downregulated genes involved in lung destruction and inflammation, while upregulating genes involved in tissue repair. Addition of 10 nanomolar GHK to lung fibroblasts from emphysema lungs restored their ability to remodel collagen and assemble it into properly organized fibrils.[30]

And for References:

30. Jump up ^ Campbell J.D., McDonough J.E., Zeskind J.E., Hackett T.L., Pechkovsky D.V., Brandsma C.A., Suzuki M., Gosselink J.V., Liu G., Alekseyev Y.O., Xiao J., Zhang X., Hayashi S., Cooper J.D., Timens W., Postma D.S., Knight D.A., Marc L.E., James H.C., Avrum S. A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. Genome Med. 2012 Aug 31;4(8):67. [Epub ahead of print]

As I see it, it is only just being studied with Aug. 2012 being the date for the study on emphysema. Seems like there's a long way to go and I see no mention of 'how' it would be used. I know a lot of things seems 'logical' to be used directly to the lung as in nebulizing, but then my dr had me nebulizing morphine and I found little to no relief from using it that way.

So, ask your dr. and perhaps do some studying on this website and see who there might be you can contact to ask about it in it's usage for emphysema. If you get any good solid information, we'd love to have you share it with us. Thanks!