The article is fairly technical with lots of buzzwords etc. One key fact runs through the study. There are circumstances where people with a genetic varient will suffer from Ardrenal suppression as a result of corticosteriods.
Apparently this has been suspected with orally taken corticosteroids; But has now been shown to happen with Inhaled corticosteroids. The incidence was shown to affect up to 22% of the adults with COPD.
-------------------- Newly Discovered Genetic Variant Could Help Predict Common Asthma Therapy Side Effect
In the first study of its kind, new research has linked inhaled corticosteroids (ICS) to adrenal suppression in asthma and chronic obstructive pulmonary disease (COPD) patients who have a genetic variant in the platelet-derived growth factor D (PDGFD) gene.
“Not only did we identify a completely novel locus in PDGFD, but we were able to validate this in another pediatric asthma cohort and then in an adult COPD cohort,” lead author Sir Munir Pirmohamed, PhD, of the University of Liverpool, told MD Magazine.
Generally, ICS are well tolerated and have less side effects than oral corticosteroids. But some asthma and COPD patients experience harmful effects, such as adrenal suppression. This can be dangerous, especially for children with asthma since their symptoms can range widely from asymptomatic, to acute adrenal crisis, where cortisol levels are insufficient.