Iron-overload and Iron-deficiency in COPD

[gerald]

Unfortunately I could only access the abstract summary.  This article indicates that a bodies improper processing of iron may cause/contribute to COPD.  And that that inability to properly process Iron eventually leads to Iron Deficiency. Without the complete article it is impossible to tell what their next steps will be.

If anyone encounters additional writeups on this it migth be worth adding them.


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The IRONy of Iron-overload and Iron-deficiency in Chronic Obstructive Pulmonary Disease
Suzanne M Cloonan , Sharon Mumby , Ian M Adcock , Augustine M. K Choi , Kian Fan Chung , and Gregory J. Quinlan

Chronic obstructive pulmonary disease (COPD) is a debilitating inflammatory lung disease associated with cigarette smoking and is third leading cause of death worldwide. With the recent emergence of genome wide association studies (GWAS), the identification of multiple COPD susceptibility genes has enhanced and expanded our understanding of the pathogenic mechanisms associated with this debilitating lung disease. An example of such a pathogenic mechanism is the role of iron metabolism in the onset and progression of COPD. Historic observations of iron dysregulation in COPD can now be enlightened by the recent revelations that genetic polymorphisms in the gene iron regulatory protein-2 (IRP-2) associate with COPD susceptibility. A functional role for IRP-2 is supported by IRP-2 overexpression in murine models, that demonstrates cellular and mitochondrial iron accumulation in the lung linked with manifestations of experimental COPD. Increased IRP2 may explain the excessive iron deposition in alveolar macrophages and tissue in smokers and in patients with COPD. Changes in IRP2 expression may also associate with systemic iron mismanagement, which may explain the prevalence of systemic iron deficiency and iron-deficiency anemia in patients with COPD. It may also help to explain why patients with COPD and/or iron deficiency manifest altered responses to hypoxia including erythropoiesis and pulmonary hypertension. We provide a concise review of the role of iron in the pathogenesis, susceptibility and progression of COPD and highlight the prospective therapeutic interventions for treating both local and systemic iron dysregulation.

www.atsjournals.org/doi/abs/10.1164/rccm.201702-0311PP

[ken]

I was and continue to be prescribed  vitamin D3 as a supplement.  This is to deal with any anemia.  This can be hard on the liver and those much needed red blood cells.  

[jarca]

i take vit D3 because i was low of that one vitamin when tested (my calcium & everything else were fine).
i have been amazed at all the things it seems to help 'absorb'----the iron is a new one for me; amazing what a bit of sunshine can do!!!!
for me it was a wonderful day to hear that my bone density had improved from "osteoporosis @ fracture level" up to "osteopenia"....
i also noticed a big difference in my winter "seasonal affect disorder" that i don't get as depressed in the winter now.
when they made sunscreen & told people to "cover up" outside due to skin cancer i wonder if anyone realized how important the sun (vit D) was going to become?

seems they are finding vit D to help with many things! www.medicalnewstoday.com/articles/161618.php
interesting!

when i google "iron & copd" i get a lot of 'hits' all saying that iron helps copd in several ways---it is supposed to reduce inflammation also. of course i guess too much of anything can also have the opposite affect. it's all in that fine balancing act that i have such a hard time with. "if a little is good a lot is better"

[David]

I have taken Yellow Dock for my source of iron. Taken it for many years.

For people with to much iron you can take Stinging Nettle to take out any excess iron.

I also take vitamin D3.