Uric acid involvement with COPD

[gerald]

Interesting study. The full report is available through the link.  In the full report the following were their conclusions:


"Within the limits of a cross-sectional approach, our results strongly suggest that uric acid is not only a useful biomarker for single entities in COPD but also plays a central role in this disease. It is simultaneously associated with determinants of worse COPD prognosis including airway obstruction, cardiovascular comorbidities, exacerbations and physical capacity, irrespective of common risk factors. This suggests that more attention should be paid to the levels of uric acid in the evaluation of COPD disease status. The described role of uric acid should be substantiated in future targeted intervention trials."

It would be interesting to see how many of us with COPD have gout or high Uric levels

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Uric acid, lung function, physical capacity and exacerbation frequency in patients with COPD: a multi-dimensional approach

Abstract
Background

Recent investigations showed single associations between uric acid levels, functional parameters, exacerbations and mortality in COPD patients. The aim of this study was to describe the role of uric acid within the network of multiple relationships between function, exacerbation and comorbidities.

Methods

We used baseline data from the German COPD cohort COSYCONET which were evaluated by standard multiple regression analyses as well as path analysis to quantify the network of relations between parameters, particularly uric acid.

Results

Data from 1966 patients were analyzed. Uric acid was significantly associated with reduced FEV1, reduced 6-MWD, higher burden of exacerbations (GOLD criteria) and cardiovascular comorbidities, in addition to risk factors such as BMI and packyears. These associations remained significant after taking into account their multiple interdependences. Compared to uric acid levels the diagnosis of hyperuricemia and its medication played a minor role.

Conclusion

Within the limits of a cross-sectional approach, our results strongly suggest that uric acid is a biomarker of high impact in COPD and plays a genuine role for relevant outcomes such as physical capacity and exacerbations. These findings suggest that more attention should be paid to uric acid in the evaluation of COPD disease status.

respiratory-research.biomedcentral.com/articles/10.1186/s12931-018-0815-y

[gnott]

Well, here is some anecdotal information that will brand me as a Kook forever on this site!

I know better than mention it. I did once to a doctor and got only a strange stare - but your post increases my wondering ... so here goes ...

We all have small little symptoms or slight anomalies that we use as "markers" on just how well our day is going or will be going.  For me one of them is how well I eliminate (micturition). I have an enlarged prostate (purely an age issue). When I am going easily with a decent stream, it is going to be a better day. But if I wake up and it's an issue and starts deteriorating - so does my breathing.

My kids will likely use that as evidentiary at my competency hearing, but there it is. Smile.

[skate4life]

Ironically, I have had my first sign of gout just this past week. Base of thumb swollen with ruddy (purple red) leak above and below joint. While most people think of gout as men and big toe, it does happen to women but usually after menopause vs. men get it younger to start. There are common joint sites but can also hit hands. It is also far more common than people would imagine. There may be many months, even years before reoccurrence, but like copd, the events start getting closer together. Plus there are many, many causes for secondary gout and can be confused with acute arthritis. Interesting that stress being a precipitating factor - like my stress about the house at the same times as having an exacerbation. My Advil and Prednisone use probably helped to block the usual symptom of acute pain. I don't think uric acid testing my our physicians is even on their radar!

[gerald]

My gout shows up in the feet.     I find a herb combination called "goutrin" keeps it under control enough to get rid of the pain.  It is really just a conbination of  the Wild cherry juice and a few other herbs.