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Post by gerald on Jan 12, 2019 13:44:23 GMT -5
I have copied a bit of the report and provided a link. I found the report quite complex and while I think I got the idea right, will need to study it several more times.
They have completed a 6 year study that has identified what, within the body, destroys the Aveoli within the lungs. They have been able to reproduce the damage by introducing that portion of the blood into mice. These exosomes and neutriphils at the cause of damage to kidney, levers and other organs.
They have also identified some future avenues for investigation to find ways to repair the cells and prevent the damage.
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Activated PMN exosomes are pathogenic entities that cause destruction in the COPD lung
Date: January 11, 2019
Source: University of Alabama at Birmingham
Summary:
Researchers have found a novel, pathogenic entity that is a fundamental
link between chronic inflammation and tissue destruction in lungs of patients
with COPD. These exosomes from activated neutrophils caused COPD
damage when they were instilled into the lungs of healthy mice. Remarkably, neutrophil exosomes from the lung fluids of human patients with COPD and
neonates with bronchopulmonary dysplasia also caused COPD lung damage
when put into the lungs of healthy mice.
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"This pathogenic entity -- exosomes from activated polymorphonuclear leukocytes, or PMNs -- caused COPD damage when the small, subcellular particles, collected from purified PMNs, were instilled into the lungs of healthy mice. Remarkably, the UAB researchers also collected exosomes from the lung fluids of human patients with COPD and the lung fluids of neonatal ICU babies with the lung disease bronchopulmonary dysplasia; when those human-derived exosomes were instilled into the lungs of healthy mice, they also caused COPD lung damage. Damage was primarily from PMN-derived exosomes from the human lungs."
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